Modern scientists have concluded that one of the main causes of gastric ulcer is a bacterial infection. The culprit scientists called Helicobacter pylori. The waste products of this bacterium destroy the mucous membrane of the stomach and provoke inflammation. Another reason is the loss by the body of its protective functions, which can manifest itself in the form of hormonal disruption or in the peculiarities of the functioning of the immune system. Also, a violation of the production of hydrochloric acid in the stomach can lead to an ulcer.
The basis of the treatment of gastric ulcers is drug therapy, which presents 5 main groups of medicines:
Antisecretory drugs that reduce the production of hydrochloric acid. This group is represented by proton pump inhibitors (pumps) and histamine H2 receptor blockers. Antisecretory agents are highly effective drugs that have an impact on reducing the production of gastric juice and the formation of the enzyme pepsin. As a rule, the use of these medicines lasts from 4 to 8 weeks. According to indications in additional therapy anticholinergics (M1) can be used.
Gastroprotectors with bactericidal activity based on bismuth. Gastroprotectors are the latest achievement of the pharmaceutical industry, designed to promote the rapid healing of gastric ulcers. These drugs provide a comprehensive treatment. They do not just effectively remove the unpleasant symptoms of the disease (heartburn, pain, bloating), but eliminate the very cause of the ulcer – Helicobacter pylori. Therefore, their role in the effective treatment of gastric ulcer is difficult to overestimate. Preparations form a protective layer, which for a long time saves the affected areas of the mucous membrane from the influence of aggressive factors. In addition to the fact that bismuth-based drugs protect the mucosa from the influence of harmful substances, they also have an anti-inflammatory and astringent effect, and help to activate the regeneration of damaged cells of the stomach wall.
Antiprotozoal drugs and antibiotics. Antibiotics prevent infection during periods of acute peptic ulcer, suppress viruses and pathogenic bacteria, including Helicobacter pylori, improve overall health. Penicillins, tetracyclines, macrolides, and nitromidazole derivatives are included in the list of patients prescribed for an acute exacerbation of gastric ulcer.
Drugs that stimulate GI motility. Prokinetics improve the motor functions of the stomach, facilitate the process of food digestion. These medications help eliminate feelings of nausea, heartburn, and heaviness.
It is important. Stimulants of motility can not be used as independent drugs for the treatment of ulcers, they only help to alleviate the patient’s condition, without exerting any influence on the cause of the disease.
Antacids are drugs to neutralize gastric acid. The main treatment of peptic ulcer disease, as a rule, is complemented by the appointment of antacids to eliminate heartburn. Antacids quickly reduce acidity and create a protective barrier, thereby protecting the mucous membrane. Often they add anesthetics – to relieve pain. However, they do not cure the ulcer, but only relieve symptoms for a short time. The disadvantages include the fact that their reception will have to be done more and more often. Instead of antacids, which in their essence replace baking soda, you should use almost no contraindications and side effects of proton pump inhibitors.
On a note. Inhibitors are more expedient to take preemptively, and not at that moment when heartburn has already developed, since these drugs are not at all instantaneous.
Summing up, we emphasize once again that dieting with a stomach ulcer is very important. However, it is worth remembering that the only guarantee of health can be an integrated approach that combines proper nutrition and competent drug therapy with the use of modern medicines that have antibacterial activity, restore the mucous membrane and prevent relapse.